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STRECK, Inc.成立于1971年,是一家行业领先的专注于临床和科研产品研发与生产的公司。STRECK秉承创新、品质、服务的理念,为患者提供更快速准确的检测结果。STRECK的核心为稳定保存系列产品,其包括Cell Free DNA BCT、Cell Free RNA BCT、Cyto-Chex BCT、Cell Free DNA Urine Preserve及STRECK Cell Preservative, 该系列产品已广泛应用于临床研究、药物研发及疾病诊断等领域。

 

Established in 1971, Streck’s founder, Dr. Wayne Ryan, developed the company’s core technology of cell stabilization at a time when blood cells were still being counted manually using microscopes. Dr. Ryan, with a fierce passion for science and innovation, discovered that by isolating and stabilizing platelets, our laboratory scientists were able to facilitate automatic counting, leading to the development of an accurate system for calibrating platelet-counting devices.  It was a profound breakthrough for hematology laboratories around the world – one that fueled our pursuit of innovative solutions for the clinical laboratory.

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Streck的主要产品包括:

(1)标物

Body Fluids

Flow Cytometry

Chemistry

Hematology

Sickle Cells

Urinalysis

(2)收集

Collect Tubes

Preservatives

Thermometers

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艾美捷科技有限公司

全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com

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成立27年来,PBL Assay Science一直协助工业界、学术界、政府研究人员开发检测方法和解决蛋白定量问题。PBL Assay Science的产品包括高品质、高灵敏度的ELISA试剂盒、干扰素蛋白和抗体等,此外PBL Assay Science还提供超灵敏细胞因子检测服务等。

 

Now entering our 27th year, PBL Assay Science works hand in hand with industry, academic, and government researchers to help solve difficult assay development and protein quantification problems. Known as a trusted source for high quality, high sensitivity ELISAs as well as interferon proteins and antibodies, PBL has expanded our assay services capabilities, including ultrasensitive cytokine detection services, and increased our human cell-expressed cytokine and growth factor offerings.

 

PBL Assay Science的主要产品包括:

(1)Assay Kits(ELISAs;Multiplex Assays;Cell-Based Assays)

(2)Proteins(Interferons,Cytokines and Growth Factors,Interferon Decoy Receptor)

(3)Antibodies(Monoclonal Antibodies (MAbs);Polyclonal Antibodies (PAbs))

(4)Assay Services(Quantitative Immunoassays;Cell-Based Services;Reagent Development)


 Assay Kits产品列表
品名货号规格
iLite Human Type I IFN Responsive Cells511002.5 ml/vial
Human IFN-Alpha Multi-Subtype ELISA Kit (Serum, Plasma, TCM)41110-11 x 96-well plate
Human IFN-Alpha Multi-Subtype ELISA Kit (Serum, Plasma, TCM)41110-25 x 96-well plates
Human IFN-Alpha Multi-Subtype ELISA Kit (TCM)41105-11 x 96-well plate
Human IFN-Alpha Multi-Subtype ELISA Kit (TCM)41105-25 x 96-well plates
Human IFN-Alpha ELISA Kit (TCM)41100-11 x 96-well plate
Human IFN-Alpha ELISA Kit (TCM)41100-25 x 96-well plates
Human IFN-Alpha All Subtype ELISA Kit, High Sensitivity (Serum, Plasma, TCM)41115-11 x 96-well plate
Human IFN-Alpha All Subtype ELISA Kit, High Sensitivity (TCM)41135-11 x 96-well plate
Human IFN-Beta ELISA Kit41410-11 x 96-well plate
Human IFN-Beta ELISA Kit41410-25 x 96-well plates
Human IFN-Beta TCM ELISA, High Sensitivity41435-11 x 96-well plate
Human IFN-Beta ELISA Kit, High Sensitivity (Serum, Plasma, TCM)41415-11 x 96-well plate
Human IFNGR1 ELISA Kit (Serum, Plasma, Cell Lysate, TCM)415801 x 96-well plate
DIY Human IFN-Lambda 1/2/3 (IL-29/28A/28B) ELISA (TCM)61840-1Materials for 15 x 96-wells
DIY Human IFN-Lambda 2/3 (IL-28A/B) ELISA (TCM)61830-1Materials for 15 x 96-wells
Mouse IFN-Alpha All Subtype ELISA Kit, High Sensitivity (Serum, Plasma, TCM)42115-11 x 96-well plate
Mouse IFN-Alpha ELISA Kit (TCM)42120-11 x 96-well plate
Mouse IFN-Alpha ELISA Kit (TCM)42120-25 x 96-well plates
Mouse IFN-Beta ELISA Kit, High Sensitivity (Serum, Plasma, TCM)42410-11 x 96-well plate
Mouse IFN-Beta ELISA Kit, High Sensitivity (Serum, Plasma, TCM)42410-25 x 96-well plates
Mouse IFN-Beta ELISA Kit (TCM, Serum)42400-11 x 96-well plate
Mouse IFN-Beta ELISA Kit (TCM, Serum)42400-25 x 96-well plates
DIY Mouse IFN-Lambda 2/3 (IL-28A/B) ELISA (TCM)62830-1Materials for 15 x 96-wells
Pig IFN-Alpha ELISA Kit (Serum, Plasma, TCM)47100-11 x 96-well plate
Cynomolgus IFN-Beta ELISA Kit (Serum, Plasma, TCM)46415-11 x 96-well plate
Cynomolgus/Rhesus IFN-Alpha ELISA Kit (Serum, Plasma, TCM)46100-11 x 96-well plate
Human IL-22 ELISA, High Sensitivity (Serum, Plasma, TCM)41701-11 x 96-well plate
Total Human IL-15 ELISA Kit, High Sensitivity (Serum, Plasma, TCM)41702-11 x 96-well plate


 Proteins产品列表
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品名货号规格
Human IFN-Lambda 2, Human Cell Expressed11720-1≥ 1 x 10⁵ units
Human IFN-Lambda 3, Human Cell Expressed11730-1≥ 1 x 10⁵ units
Human IFN-Lambda 1, Human Cell Expressed11725-1≥ 1 x 10⁵ units
Human Erythropoietin (EPO), Ultrapure11965-1500 units
Human Interleukin 22 (Human Cell-Expressed)11701-110 μg
Human Interleukin 22 (Human Cell-Expressed)11701-250 μg
Human Interleukin 15 / IL-15Rα Heterodimer (Human Cell-Expressed)11702-110 μg
Human Interleukin 15 / IL-15Rα Heterodimer (Human Cell-Expressed)11702-250 μg
Mouse Interferon Alpha All-Subtype Neutralizing Viral Protein12185-110 μg
Mouse Interferon Alpha All-Subtype Neutralizing Viral Protein12185-2100 μg
UniversalTM Type I IFN (Human IFN-Alpha Hybrid Protein)11200-11 x 10⁵ units
UniversalTM Type I IFN (Human IFN-Alpha Hybrid Protein)11200-21 x 10⁶ units
Human IFN-Beta 1a, mammalian, carrier-free11410-21 x 10⁶ units
Human IFN-Beta (Beta 1a, Mammalian Expressed)11415-11 x 10⁵ units
Human IFN-Alpha Sampler Set11002-11 x 10⁵ units
Human IFN-Alpha 2a (Alpha A) Protein11100-15 x 10⁶ units
Human IFN-Alpha 2a (Alpha A) Protein, Carrier-Free11101-15 μg
Human IFN-Alpha 2a (Alpha A) Protein, Carrier-Free11101-220 μg
Human IFN-Alpha 2b (Alpha 2) Protein11105-11 x 10⁵ units
Human IFN-Alpha 8 (Alpha B2) Protein11115-11 x 10⁵ units
Human IFN-Alpha 10 (Alpha C) Protein11120-11 x 10⁵ units
Human IFN-Alpha 1 (Alpha D) Protein11125-11 x 10⁵ units
Human IFN-Alpha 21 (Alpha F) Protein11130-11 x 10⁵ units
Human IFN-Alpha 5 (Alpha G) Protein11135-11 x 10⁵ units
Human IFN-Alpha 14 (Alpha H2) Protein11145-11 x 10⁵ units
Human IFN-Alpha 17 (Alpha I) Protein11150-11 x 10⁵ units
Human IFN-Alpha 7 (Alpha J1)11160-11 x 10⁵ units
Human IFN-Alpha 6 (Alpha K) Protein11165-11 x 10⁵ units
Human IFN-Alpha D (Alpha 1) Protein11175-11 x 10⁵ units
Human IFN-Alpha 4a (Alpha M1) Protein11177-11 x 10⁵ units
Human IFN-Alpha 4b (Alpha 4) Protein11180-11 x 10⁵ units
Human IFN-Alpha 16 (Alpha WA) Protein11190-11 x 10⁵ units
Human IFN-Omega11395-125 μg
Human IFN-Beta 1b, E.Coli11420-11 x 10⁵ units
Human IL-28A/IFN-Lambda 2, Carrier-Free11821-125 μg
Human IL-29/IFN-Lambda 1, Carrier-Free11826-125 μg
Human IFN-Gamma11500-150 μg
Human IFN-Gamma11500-2100 μg
Cynomolgus IFN-Alpha 2 (Ile 16), Mammalian16105-11 x 10⁵ units
Rhesus/Cynomolgus IFN-Alpha 214110-11 x 10⁵ units
Feline IFN-Alpha15100-11 x 10⁵ units
Porcine IFN-Alpha17105-11 x 10⁵ units
Bovine IFN-Tau 2, Mammalian19616-11 x 10⁵ units
Mouse IFN-Beta, Mammalian12405-11 x 10⁵ units
Mouse IFN-Beta, Mammalian, Carrier-Free12410-11 x 10⁶ units
Mouse IFN-Alpha A12100-11 x 10⁵ units
Mouse IFN-Alpha 112105-11 x 10⁵ units
Mouse IFN-Alpha 4, mammalian12115-11 x 10⁵ units
Mouse IFN-Alpha 1112125-11 x 10⁵ units
Mouse IFN-Alpha 1312130-11 x 10⁵ units
Mouse IFN-Beta, E.Coli12400-11 x 10⁵ units
Mouse IFN-Beta, Carrier-Free12401-11 x 10⁵ units
Mouse IL-28B/IFN-Lambda 312820-125 μg
Mouse IL-28B/IFN-Lambda 3, Carrier-Free12821-125 μg
Rat IFN-Alpha 1, Mammalian13101-110 μg
Rat IFN-Alpha 14, Mammalian13114-110 μg
Rat IFN-Alpha 113100-11 x 10⁵ units
Rat IFN-Beta13400-11 x 10⁵ units
Rat IFN-Gamma13500-110 μg
<<
 Antibodies产品列表
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品名货号规格
Anti-Human IFN-Alpha, Clone MMHA-2 (MAb)21100-150 μg
Anti-Human IFN-Alpha, Clone MMHA-2 (MAb)21100-2500 μg
Anti-Human IFN-Alpha, Clone MMHA-1 (MAb)21105-150 μg
Anti-Human IFN-Alpha, Clone MMHA-11 (MAb)21112-150 μg
Anti-Human IFN-Alpha, Clone MMHA-13(MAb)21116-150 μg
Anti-Human IFN-Alpha, Clone MMHA-17 (MAb)21118-150 μg
Anti-Human IFN-Alpha, Clone MMHA-6 (MAb)21125-150 μg
Anti-Human IFN-Alpha, Clone MMHA-9 (MAb)21127-150 μg
Anti-Human IFN-Alpha, Clone MMHA-14 (MAb)21129-150 μg
Anti-Human IFN-Alpha, Clone MMHA-8 (MAb)21110-150 μg
Anti-Human IFN-Beta, Clone MMHB-3 (MAb)21400-150 μg
Anti-Human IFN-Beta, Clone MMHB-1 (MAb)21405-150 μg
Anti-Human IFN-Beta, Clone MMHB-2 (MAb)21410-1500 μg
Anti-Human IFN-Beta, Clone MMHB-12 (MAb)21450-150 μg
Anti-Human IFN-Beta, Clone MMHB-13 (MAb)21455-150 μg
Anti-Human IFN-Beta, Clone MMHB-14 (MAb)21460-150 μg
Anti-Human IFN-Beta, Clone MMHB-15 (MAb)21465-150 μg
Anti-Human IFN-Beta, Clone MMHB-16 (MAb)21470-150 μg
Anti-Human IFN-Alpha/Beta Receptor 1 Antibody, Clone MMHAR-321370-150 μg
Anti-Human IFN-Alpha/Beta Receptor Chain 2, Clone MMHAR-2 (MAb)21385-150 μg
Anti-Human IFN-Gamma Receptor Chain 2, Clone MMHGR-2 (MAb)21585-1250 μg
Anti-Human IFN-Lambda Receptor 1, Clone MMHLR-1 (MAb)21885-150 μg
Anti-Human IFN-Lambda Receptor 1, Clone HLR14 (MAb)21886-150 μg
Anti-Human IFN-Gamma, Clone MMHG-1 (MAb)21500-1500 μg
Anti-Human IFN-Gamma, Clone MMHG-2 (MAb)21550-1100 μg
Anti-Human IFN-Gamma Receptor Chain 2, Clone MMHGR-2 (MAb)21585-1250 μg
Anti-Human IL-28A/IFNL2, neutralizing, Clone MMHL-2 (MAb)21720-1200 μg
Anti-Human Interleukin-28B/Interferon Lambda 3, neutralizing, Clone MMHL-3 (MAb)21730-1100 μg
Anti-Human ISG15, Clone 2.1 (MAb)21900-1100 μg
Anti-Mouse IFN-Alpha, Clone RMMA-1 (MAb)22100-1250 μg
FITC Conjugated Anti-Mouse IFN-Alpha, Clone RMMA-1 (MAb)22100-325 μg
Anti-Mouse IFN-Beta, Clone RMMB-1 (MAb)22400-1250 μg
Anti-Mouse IFN-Gamma, Clone RMMG-1 (MAb)22500-1500 μg
Anti-Pig IFN-Alpha, Clone K9 (MAb)27100-1500 μg
Anti-Pig IFN-Alpha, Clone F17 (MAb)27105-1500 μg
FITC Conjugated Anti-Mouse IFN-Alpha, Clone RMMA-1 (MAb)22100-325 μg
Anti-Human IFN-Alpha, Rabbit Serum (PAb)31101-11 x 10⁵ units
Anti-Human IFN-Alpha, Sheep Serum (PAb)31110-11 x 10⁵ units
Anti-Human IFN-Alpha (All Subtypes), Rabbit Serum (PAb)31135-11 x 10⁵ units
Anti-Human IFN-Beta, Sheep Serum (PAb)31401-12 x 10⁴ units
Anti-Human IFN-Beta, Rabbit IgG, protein A purified (PAb)31405-12 x 10⁴ units
Anti-Human IFN-Beta, Rabbit Serum (PAb)31410-12 x 10⁴ units
Anti-Human IFN-Beta, Goat IgG, Affinity Purified (PAb)31420-1100 μg
Anti-Human IFN-Gamma, Rabbit Serum (PAb)31500-12 x 10⁴ units
Human Type I IFN Neutralizing Antibody Mixture39000-10.2 ml
Anti-Mouse IFN-Alpha, Rabbit Serum (PAb)32100-12 x 10⁴ units
Anti-Mouse IFN-Alpha, Chicken IgY, Purified (PAb)32120-1500 μg
Anti-Mouse IFN-Beta, Rabbit Serum (PAb)32400-12 x 10⁴ units
Anti-Mouse IFN-Beta, Rabbit IgG, Protein A purified (PAb)32401-12 x 10⁴ units
Anti-Mouse IFN-Gamma, Rabbit Serum (PAb)32500-12 x 10⁴ units
Anti-Rat IFN-Alpha, Rabbit IgG, Protein A Purified (PAb)33100-1500 μg
Anti-Rat IFN-Beta, Rabbit IgG, Protein A purified (PAb)33400-1500 μg


更多详情请联系 

艾美捷科技有限公司

全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com


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BioGems.png

艾美捷科技特约代理Biogems产品。


BioGems意为生物钻石,其产品涵盖多种荧光标记的流式抗体、具有生物活性的功能性抗体,以及流式细胞术辅助试剂,如溶血剂和破膜剂等。BioGems产品全部在美国生产,目前已拥有超过500种流式试剂和600余种重组蛋白产品。

 

Through the establishment of joint collaborations with reputable manufacturers of top-quality life-science research products such as PeproTech Inc., BioGems has positioned itself to become a highly competitive source for a wide-range of recombinant protein and flow-cytometry reagents. Currently, our catalog contains more than 600 recombinant proteins and over 500 flow cytometry reagents. To keep up with the rapidly advancing research fronts, BioGems continuously adds new products to its catalog. All of our products are subjected to a thorough and rigorous quality and performance testing to ensure that each and every product meets the highest established standards. Providing our customers with the highest-quality products at affordable prices is our goal. We are confident that the unique business arrangements of BioGems together with our highly skilled and experienced personnel will enable us to achieve this goal.

 

主要产品分类:

(1)Flow Cytometry

Conjugated Antibodies

SAFIRE Functional Antibodies

Isotype Controls

Custom and Bulk Reagents

Purified Antibodies

Buffers and Solutions

(2)Recombinant Proteins

Growth Factors & Cytokines

Animal-Free Cytokines

Chemokines

Neurotrophins

Other Proteins

Anti Cytokine & Chemokine Antibodies

(3)Small Molecules

Receptor Antagonist and Inhibitors

Receptor Agonists and Activators

(4)Pre-Coated Elisa Kits

Human

Mouse

Rat

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艾美捷科技代理Protide Pharmaceuticals品牌全系列产品


Protide Pharmaceuticals, Inc.是一家专注于生物制药生产上游工艺的创新型公司。Protide Pharmaceuticals公司的核心产品为血清替代物,其核心价值在于提供高性能、化学成分明确、无动物来源的血清替代物和定制化培养基解决方案,帮助客户大幅减少生物制品生产过程中对胎牛血清或其他动物血清的依赖。,从而提高生物制品生产的效率、一致性、安全性和合规性。

除了血清替代物,Protide Pharmaceuticals公司也提供完整的、优化的无血清培养基配方,专门设计用于支持各种哺乳动物细胞系(如CHO, HEK293, Vero, MRC-5等)在生物反应器中进行高密度培养和高产率生产目标生物分子(如抗体、病毒载体、重组蛋白)。其产品应用于再生医学、肿瘤生物学、细胞生物能量学、肿瘤免疫学、转化医学、表观遗传学,胰岛细胞移植等领域。


ProtidePharmaceuticals页面.png

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Protide Pharmaceuticals产品线

血清替代品/生物制品生产培养基

Protide Pharmaceuticals的血清替代品通过提供优质、生物一致且功能性的环境,显著改善细胞的生理状态。所有血清替代品均配制成 50 倍浓缩液,这大大降低了成本,并改善了储存和供应链活动。Protide血清替代品不含:酚红、生长因子、类固醇激素、糖皮质激素、细胞粘附分子、生长因子、类固醇激素等物质,可以在其缺失或存在的情况下进行有效研究。细胞分泌的蛋白质可以在不受污染性血清成分干扰的情况下实现高度纯化。


品名货号-规格产品描述
TCH™3001-40ml;3002-100ml;3005-100ml本血清替代品主要用于人类细胞培养及细胞分泌蛋白的生产。TCH™ 在培养其他哺乳动物细胞时同样有效,且不含动物蛋白。其成分仅包含经热处理的人源蛋白(即人血清白蛋白、人转铁蛋白、重组人胰岛素)。
VaxMax™6004-100ml;6005-500ml;6006-1L100倍浓缩液是一种高性价比产品,可显著降低总体血清需求量。在MDBK、MDCK、Vero、CRFK及猪睾丸细胞培养中,使用VaxMax™已展现出显著的产量提升。兽用疫苗生产商已采用VaxMax™来增强生产,同时降低总体成本。VaxMax™通常与0.5%至1% 的血清配合使用。
HemaPro™3300-40ml;3303-100ml本产品为无血清添加剂,专为人祖细胞培养而设计。可有效用于癌症干细胞、诱导多能干细胞和间充质干细胞 的研究。不含:促红细胞生成素;重组生长因子。
TM-235™2001-40ml;2002-100ml;2005-500ml本血清替代品具有与TCM™类似的特性,但额外添加了适用于需要更高血清浓度(通常超过10%)的细胞类型的成分。TM-235™是一种成分明确且多用途的替代品。
TCM™1001-40ml;1002-100ml;1005-500ml本产品是一种通用型血清替代品,适用于多种物种来源的广泛细胞类型。TCM™是一种成分明确且多用途的血清替代品,可有效用于研究生长因子的影响以及蛋白质的生产。


● 低温保护剂


品名货号-规格产品描述
Stemsol™ USP (DMSO)PP1250-5ml;PP1300-10ml;PP1350-50ml;PP1400-100ml本产品为干细胞冻存溶液,适用于来源于脐带血、外周血、骨髓及其他生物组织和细胞的干细胞。
pZerve™5700-60ml;5720-20mlpZerve™ 是一款独特的冻存溶液,不含 DMSO、胎牛血清或动物蛋白。本品为即用型,无需任何稀释或进一步处理。适用细胞类型包括:肥大细胞、树突细胞、间充质细胞、人转移性前列腺腺癌细胞、人结肠腺癌细胞,人转化胚肾细胞。
Cellvation™5001-60mlCellvation™ 是一款独特的冻存溶液,不含 DMSO 或胎牛血清。本品使用便捷,并能提供最佳的细胞复苏效果。在冷冻程序启动前,细胞可置于 Cellvation™ 中较长时间。本品为即用型,适用于无血清培养基或含血清培养基培养的细胞。
MiCord™ 55% DMSO USP 5% Dextran USP1505-5ml;1500-7ml;;1700-10ml;1550-50ml;1600-100ml本产品为干细胞冻存溶液,适用于来源于脐带血、外周血、骨髓及其他生物组织和细胞的干细胞。
2-8CELLsius™ + DMSO,5% DMSOPP338DM5-10ml;PP338DM5-100ml;PP338DM5-100B当与DMSO配合使用时,2-8CELLsius™可用作冻存液。2-8CELLsius™ + DMSO冻存液是一种细胞保护性、无蛋白溶液,含有生物稳定剂,可支持冻融后细胞的高存活率。其通过针对超低温下细胞生理学的创新方法,实现最佳的细胞复苏效果。不含:任何生长因子,激素以及抗生素。
2-8CELLsius™ + DMSO,10% DMSOPP338DM10-10ml;PP338DM10-100ml;PP338DM10-100B;PP338DM10-1000B
2-8CELLsius™ + DMSO,20% DMSOPP338DM20-100B;PP338DM20-1000B


细胞处理


品名货号-规格产品描述
2-8CELLsius™PP338-100ml;PP338-500ml;PP338-1000;PP338-1000B即用型、平衡、细胞保护性、无蛋白溶液,含生物稳定剂,适用于:短期储存、再生医学、干细胞处理以及生物材料运输。
Dextran 40 in 0.9% NaClPP1850-50ml;PP1840-1000ml;PP1880-250ml;PP1900-500ml-
Dulbecco’s Phosphate Buffered Saline (10X) PBSPBS210-500ml;PBS211-1000ml无钙镁储存条件:15-30°C;包装于PETG瓶;稳定性:至少6个月;无菌过滤
Dulbecco’s Phosphate Buffered Saline (1X) PBSPBS200-500ml;PBS201-1000ml无钙镁储存条件:15-30°C;包装于PETG瓶;稳定性:至少6个月;无菌过滤
Hank’s Balanced Salt Solution (1X) HBSSHS240-500ml;HS241-1000ml无钙镁配方:储存温度 4-8°C;无酚红配方;稳定性:至少6个月;含0.35克/升 碳酸氢钠;含1000毫克/升 D-葡萄糖;包装于 PETG 瓶,无菌过滤。cGMP 规范生产。


● CIT 胰岛细胞溶液


品名货号-规格
Cold Storage/Purification Stock Solution111098-1L
Phase I Solution060899-1L


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艾乐美生物科技有限公司(AllerMAbs Co., Ltd.)成立于2015年,是台湾一家专注于生产高亲和力、高纯度并具有过敏原特异性的嵌合人类IgE单克隆抗体的生物公司。公司创办人团队在科研过程中发现市面上缺乏多样的IgE单克隆抗体,特別是具有过敏原特异性的人IgE 单抗。如果能制备出这种抗体,将有助于IgE 相关领域的研究工作。因此,AllerMAbs公司团队开始思考与研究利用基因克隆动物来制造人类 IgE 抗体的可行性,经过数年的努力于 2014年开发出人类IgE 抗体基因嵌入小鼠,通过杂交瘤技术 (Hybridoma technology),成功地研制出分泌嵌合人类IgE 单抗的 IgE 杂交瘤与纯化 IgE 抗体。经测试,此种嵌合人类IgE 单抗的物化性质与对免疫细胞的活性,皆与人类IgE 抗体一致,研究成果于2015 年发表在国际学术期刊上。

 

AllerMAbs的产品解决了目前人类IgE抗体不易制备的问题,让嵌合人类IgE抗体可以成为人类IgE抗体的替代品,并提供一个更稳定、更符合血清IgE检测系统的校正品,让临床血清IgE的检测结果更加准确与可靠。

 

其利用动物基因转殖技术,将组成人类IgE抗体分子的ε重链(Heavy chain)和κ轻链(Light chain)的编码基因(Encoding genes),分別嵌入(Knock-in)小鼠胚胎干细胞(Embryonic stem cells, ES cells)的γ1重链和κ轻链基因的位置,接着把胚胎干细胞分別植入孕母鼠体内,并将其带有嵌入基因之成鼠交互配种,最后得到带有人类IgE抗体重链和轻链基因的基因嵌入小鼠(HεκKI mice),且体内能制造完整的嵌合人类IgE抗体分子。

 

技术优势

容易制备IgE杂交瘤与IgE单抗

过敏原特异性

良好的亲和力与专一性

高纯度与高稳定性

可结合至嗜碱性粒细胞上的IgE受体与刺激細胞

可大量生产与高浓度制备

非人类血液来源(相较于血清IgE抗体)

适合用作检测用的校正品

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